Innate immune processes are sufficient for driving silicosis in mice

Sliver nanoparticles accelerate skin wound healing in mice (Mus musculus) through suppression of innate immune system

Objective(s): This study aimed to find the effects of silver nanoparticles (Ag-NPs) (40 nm) on skin wound healing in mice Mus musculus when innate immune system has been suppressed.Materials and Methods: A group of 50 BALB/c mice of about 8 weeks (weighting 24.2±3.0 g) were randomly divided into two groups: Ag-NPs and control group, each with 25 mice. Once a day at the same time, a volume of 50...

Border Disease Control Checkpoints: Are They Sufficient for Disease Control? The Present Situation in Thailand

Innate Immune Responses in Mice The Tumor Suppressor ARF Regulates

Toll-like receptors are key participants in innate immune responses.

During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. These type I transmembrane receptors identify microbial conserved structures or pathogen-associated...

Innate Immune Responses Are Increased in Chronic Obstructive Pulmonary Disease

BACKGROUND Chronic obstructive pulmonary disease (COPD) is characterised by irreversible airflow obstruction, neutrophilic airway inflammation and chronic bacterial colonisation, however the role of the innate immune response in the pathogenesis of COPD remains unclear. METHODS Induced sputum was obtained from adults with COPD (n=22), and healthy controls (n=29) and was processed for differen...